![]() ![]() Correlation during human neonatal CPR needs further investigation.Īlthough the need for neonatal cardiopulmonary resuscitation (CPR) in the delivery room is rare ( 1, 2), morbidity and mortality rates are extremely high for newborns requiring CPR ( 3). When using ETCO 2 to guide uninterrupted CPR in this model of asphyxia-induced asystole, auscultative confirmation of return of an adequate HR should be performed when ETCO 2 ≥14 mm Hg is achieved. An ETCO 2 cut-off value of 14 mm Hg is the most sensitive ETCO 2 value with the least false positives. A receiver operator curve was generated using the calculated sensitivity and specificity for various ETCO 2 values, where a positive test was defined as the presence of HR >60 bpm by auscultation. ![]() HR was auscultated every 30 s, and ETCO 2 was continuously recorded. Resuscitation followed current neonatal guidelines with initial ventilation with 100% O 2 followed by cardiac compressions followed by epinephrine for continued asystole. Neonatal swine ( n = 46) were progressively asphyxiated until asystole occurred. Our objective was to determine the threshold ETCO 2 that is associated with ROSC after asphyxia-induced asystole. However, the ETCO 2 value that correlates with an audible HR is unknown. End-tidal CO 2 (ETCO 2) monitoring may provide a continuous noninvasive method of assessing return of spontaneous circulation (ROSC) without stopping to auscultate for heart rate (HR). Even brief interruption of cardiac compressions significantly reduces critical coronary perfusion pressure during cardiopulmonary resuscitation (CPR).
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